Nafcilina [INN-Spanish]

Nafcilina [INN-Spanish] Brand names, Nafcilina [INN-Spanish] Analogs

Nafcilina [INN-Spanish] Brand Names Mixture

No information avaliable

Nafcilina [INN-Spanish] Chemical_Formula

C₃₃H₄₇NO₁₃

Nafcilina [INN-Spanish] RX_link

http://www.rxlist.com/cgi/generic2/natamycin.htm

Nafcilina [INN-Spanish] fda sheet

Nafcilina [INN-Spanish] msds (material safety sheet)

Nafcilina [INN-Spanish] Synthesis Reference

No information avaliable

Nafcilina [INN-Spanish] Molecular Weight

665.725 g/mol

Nafcilina [INN-Spanish] Melting Point

290 ^oC

Nafcilina [INN-Spanish] H₂O Solubility

4100 mg/L

Nafcilina [INN-Spanish] State

Solid

Nafcilina [INN-Spanish] LogP

0.495

Nafcilina [INN-Spanish] Dosage Forms

Ophthalmic suspension (5%)

Nafcilina [INN-Spanish] Indication

For the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms including Fusarium solani keratitis.

Nafcilina [INN-Spanish] Pharmacology

Natamycin is an antifungal drug for topical ophthalmic administration. It is a tetraene polyene antibiotic derived from Streptomyces natalensis. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Although the activity against fungi is dose-related, natamycin is predominantly fungicidal. Natamycin is not effective in vitro against gram-positive or gram-negative bacteria. Topical administration appears to produce effective concentrations of natamycin within the corneal stroma but not in intraocular fluid.

Nafcilina [INN-Spanish] Absorption

Systemic absorption should not be expected following topical administration, and as with other polyene antibiotics, absorption from the gastrointestinal tract is very poor.

Nafcilina [INN-Spanish] side effects and Toxicity